The table below shows the comparison between the ND-100 and the ND-100S:
As for the drivers, the ND-100S utilizes the same ones used for the ND-100: (http://www.usglobalsat.com/corp/p-590-nd-100s.aspx
Also shown in the table above, the following devices have different software and the reason for that is based on the chipset inside the device. Since the ND-100 has MStar chip, it uses the MStar AP. On the other hand, the ND-100S has SiRF Star III chip and it utilizes the GPS Software. This test software also works with any of our USB and Bluetooth GPS Receivers.
Moreover, the ND-100 Firmware Update would not work with the ND-100S.